Penicillin

by Sara Travassos, 11º B
Escola Secundária de Loulé


Penicillin is a group of antibiotics derived from Penicillium fungi that are used as antibiotics in the treatment of bacterial infections. Penicillin is one of the earliest discovered and widely used antibiotic agents, derived from the Penicillium mold. Antibiotics are natural substances that are released by bacteria and fungi into the their environment, as a means of inhibiting other organisms - it is chemical warfare on a microscopic scale.


Figure1. Penicillium fungi

The term "penicillin" can also refer to the mixture of substances that are naturally produced.
Originally noticed by a French medical student, Ernest Duchesne, in 1896. Penicillin was re-discovered by bacteriologist Alexander Fleming working at St. Mary's Hospital in London in 1928. He observed that a plate culture of Staphylococcus had been contaminated by a blue-green mold and that colonies of bacteria adjacent to the mold were being dissolved. He showed that if the mold Penicillium notatum was grown in the appropriate substrate, it would exude a substance with antibiotic properties, which he dubbed "penicillin". This observation began the modern era of antibiotic discovery.

Figure 2. Penicillin biosythesis. Credit: Wikipedia

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